ZLN-024 hydrochloride ( ZLN024 hydrochloride )

Catalog No. M16965 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ZLN-024 hydrochloride
Note

Research use only, not for human use.
Brief Description

A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
Description

A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively; also directly activate recombinant AMPK α1β2γ1 (EC50=1.1 μuM) and AMPK α2β2γ1 (EC50=0.13 uM); activates AMPK in L6 myotubes and stimulates glucose uptake and fatty acid oxidation; improves glucose tolerance, liver tissue weight, triacylglycerol and decreases the total cholesterol content in db/db mice (15 mg/kg/day).Diabetes Preclinical
Synonyms

ZLN024 hydrochloride
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK
Research Area

——
Indication

——

CAS Number

--
Formula Weight

361.69
Molecular Formula

C13H14BrClN2OS
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 46 mg/mL
SMILES

——
Chemical Name

Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-, hydrochloride

1. Zhang LN, et al. PLoS One. 2013 Aug 20;8(8):e72092.

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