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Home - Products - Membrane Transporter/Ion Channel - AMPK - ZLN-024 hydrochloride

ZLN-024 hydrochloride

CAS No. ——

ZLN-024 hydrochloride( ZLN024 hydrochloride )

Catalog No. M16965 CAS No. ——

A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ZLN-024 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
  • Description
    A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively; also directly activate recombinant AMPK α1β2γ1 (EC50=1.1 μuM) and AMPK α2β2γ1 (EC50=0.13 uM); activates AMPK in L6 myotubes and stimulates glucose uptake and fatty acid oxidation; improves glucose tolerance, liver tissue weight, triacylglycerol and decreases the total cholesterol content in db/db mice (15 mg/kg/day).Diabetes Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ZLN024 hydrochloride
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    AMPK
  • Recptor
    AMPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    361.6851
  • Molecular Formula
    C13H14BrClN2OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 46 mg/mL
  • SMILES
    ——
  • Chemical Name
    Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-, hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang LN, et al. PLoS One. 2013 Aug 20;8(8):e72092.
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